Two new steroidal saponins from Maianthemum henryi and their cytotoxic activity against human HepG2 tumor cells

Abstract

Two new steroidal saponins (1 and 2), along with four known ones (3 ∼ 6) were obtained from the roots and rhizomes of Maianthemum henryi, their structures were determined to be spirost-5, 25(27)-diene-lβ, 3β-diol 1-O-α-L-rhamnopyranosyl-(1 → 2)-4-O-acetyl-β-D-fucopyranoside (1), (23S, 24S)-spirost-5, 25(27)-diene-lβ, 3β, 23, 24-tetrol 1-O-α-L-rhamnopyranosyl-(1 → 2)-4-O-acetyl-β-D-fucopyranoside (2), spirost-5, 25(27)-diene-lβ, 3β-diol 1-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-fucopyranoside (3), spirost-5, 25(27)-diene-lβ, 3β-diol 1-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-xylopyranoside (4), Henryioside A (5)、Henryioside B (6), by physicochemical properties and spectroscopic methods. In addition, their cytotoxic activity against human HepG2 tumor cells was evaluated by MTT method and all of the compounds exhibited cytotoxicity with the cells.

Keywords:

• Maianthemum henryi
• steroidal saponins
• structure evaluation
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplementary data associated with this article can be found, in the online version, at http://www.tandfonline.com/

Additional information

Funding

This project was financially supported by the Research Project of key Laboratory of Education Department of Shaanxi Province (grant No. 15JS025), Fundamental Research of Natural Science of Shaanxi Province (grant No. 2014JM2-8187), Promotion of Innovative Talents Project of Shaanxi province of Science and Technology Department (grant No. 2017KJXX-81).