http://orcid.org/0000-0003-4652-6879
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Abstract
Five new lanostane-type triterpenoids, named piptolinic acids F − J (1–5), as well as seven known analogues (6–12), were isolated from methanolic extract of the fruiting bodies of Piptoporus betulinus. Compounds 1–4 were 24-methyl-lanostane triterpenoids, while compound 5 was a 3,4-seco-lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound 6 exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC50 = 42.8 μM) and human renal carcinoma cell line 786-O (IC50 = 56.5 μM).
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Natural Science Foundation of China (U1703331, 81773998, 21502222), Xinjiang Key Research and Development Program (2016B03038-3), and the Recruitment Program of Global Experts (to Yuan), China.
