Secondary metabolites isolated from the deep sea-derived fungus Aspergillus sydowii C1-S01-A7

Abstract

Two novel compounds, 2-hydroxy-6-formyl-vertixanthone (1) and 12-O-acetyl-sydowinin A (2), were obtained from the culture of a deep sea-derived fungus Aspergillus sydowii C1-S01-A7, together with twenty-two known compounds (3–24). Their structures were elucidated based on extensive spectroscopic methods. Compounds 4, 8 and 12 showed antibacterial activities against Vibrio rotiferianus and Vibrio vulnificus. Compounds 1, 2, 7, 8, 11 and 12 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus. Remarkably, compound 8 displayed selectively cytotoxic activity against A549 and strongest cytotoxic activities for both A549 and HepG2 in comparison to the remaining compounds.

KEYWORDS:

• Aspergillus sydowii
• xanthone
• antibacterial
• cytotoxic

Acknowledgement

We would like to thank all the members of Scientific Instruments Sharing Platform in Third Institute of Oceanography for their assistance in this work. This research was supported by COMRA program [DY135-B-01] and [DY135-B-05], Scientific Research Foundation of Third Institute of Oceanography SOA [2017001] and [2018021], and Bilateral Cooperation of Maritime Affairs [HC180301].

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

COMRA program [DY135-B-01] and [DY135-B-05], Scientific Research Foundation of Third Institute of Oceanography SOA [2017001] and [2018021], and Bilateral Cooperation of Maritime Affairs [HC180301].