Natural Product Research

Formerly Natural Product Letters

Volume 33, 2019 - Issue 21

190

Views

CrossRef citations to date

Altmetric

Short Communications

New benzyl-aporphine alkaloids from Thalictrum cultratum

Wenjia KangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

Jianyong LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

Dahong LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

Zhanlin LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

http://orcid.org/0000-0001-5306-3396

Shengshuang ChenKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

Huiming HuaKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. ChinaCorrespondence[email protected] [email protected]

Jiao BaiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. ChinaCorrespondence[email protected] [email protected]

show all

Abstract

Two new rare benzyl-aporphine alkaloids, thaliculine (1) and 6a,7-dehydrothaliculine (2), were isolated from the roots of Thalictrum cultratum Wall. Their structures were determined based on spectroscopic analysis including 1D, 2D NMR, and HR-ESI-MS. The stereochemistry of 1 was assigned by ECD spectroscopy. Compound 1 exhibited weak cytotoxicity against HL-60 cell line with IC₅₀ value of 31.40 μM.

Keywords:

Acknowledgments

This work was supported by the Program for Innovative Research Team of the Ministry of Education and the Program for Liaoning Innovative Research Team in University.

Disclosure statement

No potential conflict of interest was reported by the authors.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

New benzyl-aporphine alkaloids from Thalictrum cultratum

Related Research Data

Information for

Open access

Opportunities

Help and information

New benzyl-aporphine alkaloids from Thalictrum cultratum

Abstract

Acknowledgments

Disclosure statement

Reprints and Corporate Permissions

Academic Permissions

Related Research Data

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature