Fupyrones A and B, two new α-pyrones from an endophytic fungus, Fusarium sp. F20

Abstract

Two new α-pyrones, fupyrones A and B (1 and 2) and a biosynthetically related known α-pyrone, 4-methyl-5,6-dihydro-2H-pyran-2-one (3), were isolated from an endophytic fungus, Fusarium sp. F20, harbored in the stems of the Chinese medicinal plant Mahonia fortunei. Their structures were determined on the basis of spectroscopic data including MS and NMR. The antibacterial efficacies of compounds 1–3 were evaluated against four selected Gram-positive and Gram-negative bacteria, and their quorum sensing inhibitory activity was also investigated against the test organism, Chromobacterium violaceum.

Keywords:

• Endophytes
• natural products
• α-pyrones
• bioactivities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported financially by the Scientific Research Foundation of Qingdao University [grant number 29016010007010].