http://orcid.org/0000-0002-4669-631X
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Abstract
A novel acylated quercetin glycoside, floralpanasenoside A (1) and five known flavonoid glycosides, panasenoside (2), quercetin 3-O-(2''-β-D-glucopyranosyl)-β-D- galactopyranoside (3), trifolin (4) kaempferol 7-O-α-L-rhamnoside (5), and afzelin (6) were isolated from the flower buds of Panax ginseng. Their structures were established by spectroscopic data and comparison with the literature values. Four of the six isolated compounds including 1 (IC50 = 62.4) exhibited α-glucosidase inhibitory activity with IC50 values lower than acarbose (385.2 μM). The molecular docking study indicated that 1 bound to the active site of α-glucosidase with numerous hydrogen bond interactions.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This project was supported by the National Natural Science Foundation of China (81603272); the College Innovation Team Project of Liaoning Province (LT2016017); the High-level Talent Innovation Support Program of Dalian (2017RQ152); Science and Technology Innovation Foundation of Dalian City (2018J12SN062).
