http://orcid.org/0000-0001-7273-0131
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Abstract
Twenty-two alkaloids, were isolated from Fumaria densiflora. Two of these alkaloids, N-methyl-5-hydroxystylopine chloride and fumaricine N-oxide, were isolated for the first time from natural sources. Parfumine and fumaritine, in concentrations ranging from 3 × 10−7 to 9 × 10−4 M, caused concentration–dependent relaxation of ileum longitudinal segment. Also, parfumine and fumaritine in concentrations ranging from 3 × 10−4 to 9 × 10−2 M, caused concentration – dependent decrease in heart rate of the isolated perfused heart. A concentration of parfumine of 3 × 10−2 M increased but a higher concentration (9 × 10−2 M) decreased the amplitude of contraction of the isolated perfused heart. On the other hand, fumaritine, in concentrations ranging from 3 × 10−4 to 3 × 10−2 M, caused concentration – dependent increase, but a higher concentration (9 × 10−2 M) caused a decrease in the amplitude of contraction of the isolated perfused heart.
Disclosure statement
No potential conflict of interest was reported by the authors.
