Protective effect of phenolic acids from Chebulae Fructus immaturus on carbon tetrachloride induced acute liver injury via suppressing oxidative stress, inflammation and apoptosis in mouse

Abstract

Chebulae Fructus immaturus, a traditional Tibetan medicine, originated from the immature fruit of Terminalia chebula Retz., has been proven to have antioxidat function. However, its protection to injury liver cell caused by carbon tetrachloride (CCl₄) has not been clarified. This study evaluated the effect of phenolic acid from Chebulae Fructus immaturus (PATC) on CCl₄-induced acute liver injury in mice and related molecular mechanisms. Our data showed that PATC had convincing protective effects on the CCl₄-induced acute liver injury by enhancing the anti-oxidative defense system, ameliorating inflammation and inhibiting the hepatocyte apoptosis.

Graphical Abstract

Keywords:

• Chebulae Fructus immaturus
• penolic acid
• CCl4 hepatotoxicity
• antioxidant
• anti-inflammatory
• anti-apoptosis

Disclosure statement

The authors declare no conflicts of interest or financial interests.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (81702995, 81703678, 81703673 and 81573734), Dalian outstanding youth science and technology talent project, Program for the Outstanding Innovative Teams of Higher Learning Institutions of Liaoning (LR2016064), Basic scientific research projects of colleges and universities (LQ2017038), Dalian Medical University Special Grant for Translational Medicine (106061) and Liaoning Province Natural Science Fund (20180550087).