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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 24
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Research Articles

Antibiotic angucycline derivatives from the deepsea-derived Streptomyces lusitanus

Lu Yanga Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, ChinaView further author information
,
Lukuan Houa Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, ChinaView further author information
,
Huayue Lia Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China;b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Wenli Lia Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China;b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaCorrespondence[email protected] [email protected]
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Pages 3444-3450 | Received 22 Oct 2018, Accepted 30 Jan 2019, Published online: 05 Mar 2019
 
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Abstract

A new (1, grincamycin L) and two known (2 and 3) angucycline derivatives were obtained from the fermentation of deepsea-derived Streptomyces lusitanus OUCT16-27 strain. The structures of 1–3 were elucidated based on the LC-MS analysis together with 1D and 2D NMR data assignment. In the antibacterial assay, 1 and 2 exhibited moderate growth inhibitions against multi-drug resistant (MDR) strains of E. faecium, E. faecalis and S. aureus with the minimum inhibitory concentrations (MICs) of 3.12–6.25 µg/mL.

Graphical Abstract

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China under grants 21502180, 81561148012, 31570032 and 41506157, the NSFC-Shandong Joint Fund for Marine Science Research Centers under grants U1706206 and U1406403, and the Science and Technology Project of Qingdao under grant 17-3-3-44-nsh.

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