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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 4
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Short Communications

Secondary metabolites from the aerial parts of Sideritis germanicopolitana and their in vitro enzyme inhibitory activities

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Pages 655-658 | Received 22 Dec 2018, Accepted 20 Feb 2019, Published online: 11 May 2019
 

Abstract

Three iridoid glycosides, 5-allosyloxy-aucubine (1), melittoside (2), ajugol (3), five phenylethanoid glycosides, verbascoside (4), martynoside (5), leucoseptoside A (6), lamalboside (7), decaffeoylverbascoside (8), four flavonoids, xanthomicrol (9), isoscutellarein 7-O-[6'''-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyranoside (10), 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyranoside (11), 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-β-allopyranosyl-(1→2)]-β-glucopyranoside (12), and two lignan glycosides dehydrodiconiferylalcohol 4-O-β-D-glucopyranose (13) and pinoresinol 4'-O-β-glucopyranoside (14) were isolated from the aerial parts of Sideritis germanicopolitana. Their structures were determined on the basis of detailed NMR and HRESIMS analyses. To our knowledge, all compounds are being reported for the first time from S. germanicopolitana, while the isolated lignans (13 and 14) are new for the genus Sideritis. In vitro evaluation of AChE, BChE and LOX inhibitory effects of all the tested compounds (114) resulted in low to moderate activities.

Disclosure statement

The authors declare that there is no potential conflict of interest referring to this article.

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