http://orcid.org/0000-0002-7152-7040
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Abstract
One new lignan, loniceralanside A (1), together with three known compounds (2–4), were purified from Lonicerae Japonicae Flos. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR data. Compounds 2–4 were separated from the plant for the first time. The biological test showed that compound 1 had significant anti-inflammatory activity with inhibiting the release of β-glucuronidase induced by platelet-activating factor (PAF) in rat polymorphonuclear leukocytes (PMNs) (IC50 = 3.05 µM).
Graphical Abstract
Acknowledgements
We are grateful to Shandong University of Traditional Chinese Medicine for the donation of plant materials.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Standardization Project Fund of Administration of Traditional Chinese Medicine [grant number: ZYBZH-Y-SD-32], Postdoctoral Science Foundation of China [grant number: 2017M622268], Specialized Fund for Dependent Innovation of Shandong Province [grant number: 2016GSF202009].