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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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A new griseofulvin derivative from a soft coral-derived fungus Eupenicillium sp. SCSIO41208

Yunqiu LiSchool of Pharmacy, Guilin Medical University, Guilin, P. R. China; View further author information
,
Yanhong TanSchool of Pharmacy, Guilin Medical University, Guilin, P. R. China; ;Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
,
Juan LiuKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
,
Xuefeng ZhouKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
,
Siquan ZengKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
,
Junde DongKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
,
Yonghong LiuKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaView further author information
&
Bin YangKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. ChinaCorrespondence[email protected]
View further author information
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Pages 2971-2975 | Received 12 Jan 2019, Accepted 04 Mar 2019, Published online: 08 Apr 2019
 
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Abstract

A new griseofulvin derivative, eupenigriseofulvin (1), together with six known compounds, griseofulvin (2), dechlorogriseofluvin (3), dechloroisogriseofulvin (4), trichopyrone (5), 2-(4-hydroxyphenyl)-ethanol (6), and 1-phenylethane-1,2-diol (7), were isolated from the EtOAc extract of Eupenicillium sp. SCSIO41208. The structures of these compounds were elucidated by spectroscopic methods including NMR and mass spectrometry. The absolute configuration of 1 was determined on the basis of electronic circular dichroism (ECD) data analysis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by grants from the National Natural Science Foundation of China (81860626, 81741158), Guangzhou Scientific Research Project (201804010462).

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