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Abstract
Two new sorbicillinoids, 13-hydroxy-dihydrotrichodermolide (1) and 10,11,27,28-tetrahydrotrisorbicillinone C (2), were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with Kd values of 0.0285 μM, 0.0162 μM for GLP-1R and 0.118 μM, 0.0746 μM for eEF2K, respectively.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by National Key Research and Development Program of China [grant number 2018YFC0310900]; National Natural Science Fund of China [grant number U1605221]; Shanghai Municipal Health Commission excellent young talent program [grant number 2018YQ28]; Sichuan Science and Technology Program [grant number 2018JZ0017].
