Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii

Abstract

Astragalus ernestii has been used as a substitute for Radix Astragali (Huang-Qi) in southwest China. To better understand the chemical rationale for the medicinal usage, the phytochemistry of A. ernestii was recently studied. As a result, a novel aurone-phenylpropanoid adduct astrernestin (1), together with five known phenoloids calycosin-7-O-β-D-glucopyranoside (2), 4,4′-dimethoxy-3′-hydroxy-7,9′:7′,9-diepoxylignan-3-O-β-D-glucopyranoside (3), syringaresinol-4-O-β-D-monoglucoside (4), hedyotol D 4″-O-β-D-glucopyranoside (5) and trifolirhizin (6), were isolated from the roots of A. ernestii. The structure of compound 1 was elucidated by extensive spectroscopic analysis and optical rotation calculation.

Graphical Abstract

Keywords:

• Astragalus ernestii
• Leguminosae
• chemical constituents
• structural elucidation
• optical rotation calculation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China [grant number 31170313], as well as the Innovation Team Project of Dali University for the Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines [ZKLX2019106].