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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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Research Articles

Terpenoids and phenolics of Micromeria persica

Sakineh Kalaki KordkolaeiDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran;
,
Mohammad Reza KananiDepartment of biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran;
,
Marzieh TabefamDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran;
,
Nazanin Namazi SarvestaniDepartment of Animal Biology School of Biology College of Science, University of Tehran, Tehran, Iran;
,
Matthias HamburgerDepartment of Pharmaceutical Sciences Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
&
Mahdi Moridi FarimaniDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran; Correspondence[email protected]
Pages 2913-2918 | Received 08 Oct 2018, Accepted 16 Mar 2019, Published online: 16 Apr 2019
 
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Abstract

Phytochemical investigation of the aerial parts of Micromeria persica led to the isolation of a new oleane type triterpenoid ester (1), together with six known compounds 2–7), comprising one phenyl ethanoid ester, one glycosylated flavonoid, two triterpenoids, and two steroids. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1 and 3 were evaluated for their cytotoxic feature against human breast adenocarcinoma cell line (MDA-MB231) and human prostate cancer cell line (DU145). However, they did not show positive effect (IC50 > 75µM).

Acknowledgement

Financial support by the Shahid Beheshti University Research Council is gratefully acknowledged. Thanks are due to T. Hettich (School of Life Sciences, University of Applied Sciences, Institute for Chemistry and Bioanalytics, Muttenz) for the HRESIMS data.

Disclosure statement

No potential conflict of interest was reported by the authors.

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