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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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Research Articles

Two new secondary metabolites from the mangrove endophytic fungus Pleosporales sp. SK7

Shitong WenSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaView further author information
,
Weilong FanSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaView further author information
,
Huixian GuoSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaView further author information
,
Cuiying HuangSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaView further author information
,
Zhangyuan YanSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaView further author information
&
Yuhua LongSchool of Chemistry and Environment, South China Normal University, Guangzhou, ChinaCorrespondence[email protected]
View further author information
Pages 2919-2925 | Received 09 Jan 2019, Accepted 19 Mar 2019, Published online: 10 Apr 2019
 
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Abstract

Two new compounds, an abscisic acid-type sesquiterpene (1), and one asterric acid derivative (2), together with three known compounds (3–5) were isolated from mangrove endophytic fungus Pleosporales sp. SK7. The structures of these metabolites were determined by NMR, X-ray crystal diffraction, CD and HR-ESI-MS. All compounds were tested for their antibacterial, antioxidant and cytotoxic activities, among these compounds, 5 showed cytotoxicity against MDA-MB-435 cell with an IC50 of 25.96 ± 0.32 μM.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The authors gratefully acknowledge grants from the National Natural Science Foundation of China (Nos. 41876153, 41376149), the Natural Science Foundation of Guangdong Province (2017A030313088), and GDME-2018C004.

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