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Abstract
Three new triterpenoids, 2α, 3α, 20β, 23-tetrahydroxyurs-13 (18)-en-28-oic-acid (1) (Figure 1), 2β, 3α, 20β, 23-tetrahydroxyurs-13(18)-en-28-oic-acid (2), and 2α, 3α-dihydroxyurs-12(13), 18(19)-dien-28-oic-acid (3) were isolated from the roots of R. cymosa. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and IR spectroscopic analyses data. All the isolates were evaluated for their α-glucosidase inhibitory and anti-inflammatory activities in vitro. The results showed that compound 2 displayed moderate anti-inflammatory activity with IC50 value of 9.4 μM.
Graphical Abstract
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Acknowledgements
This work was financially supported by the technological platform for comprehensive research and development of new drugs in the Twelfth Five-Year “Significant New Drugs Created” Science and Technology Major Projects (No. 2012ZX09301-002-001-026), the National Science and Technology Support Program (No. 2012BA127B06).
Disclosure statement
No potential conflict of interest was reported by the authors.
Figure 1. Structures of compounds 1–3.
