http://orcid.org/0000-0003-0260-3334
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Abstract
A pair of new neo-clerodane diterpenoid epimers, 3S-methoxyl-teucvin (1) and 3R-methoxyl-teucvin (2), were isolated from the Roots of Croton crassifolius. Their structures were completely established on the basis of spectroscopic methods, and the absolute configurations were determined by analysis of electronic circular dichroism (ECD) spectroscopy and X-ray diffraction analysis. Compounds 1 and 2 exhibited anti-inflammatory activities with IC50 values of 0.82 and 0.54 μM, respectively, while the IC50 value of dexamethasone as a positive control was found to be 0.14 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Program for National Natural Science Foundation of China [grant number 81703392]; the Key Research and Development Program of Shaanxi Province [grant number 2017SF-365]; the Natural Science Foundation of Shaanxi Provincial Department of Education (grant number 16JK1196).
