Two new sixteen-membered macrolides from the genetically engineered strain Streptomyces avermitilis MHJ1011

Abstract

Two new sixteen-membered macrolides, Δ^2,3-tenvermectin A (1) and 13α-hydroxy milbemycin β₁₁ (2), were isolated from the fermentation broth of the genetically engineered strain Streptomyces avermitilis MHJ1011. Their structures were determined based on extensive spectroscopic analysis and comparison with related known compounds. Compounds 1 and 2 exhibited potent acaricidal activity against Tetranychus cinnabarinus.

Keywords:

• Streptomyces avermitilis MHJ1011
• sixteen-membered macrolides
• Δ^2,3- tenvermectin A
• 13α-hydroxy milbemycin β₁₁
• acaricidal activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China (31471809).