One new benzophenone and one new 1,3-diphenylpropane from the fibrous roots of Anemarrhena asphodeloides Bge. and their cytotoxicity

Abstract

One new benzophenone (1) and one new 1,3-diphenylpropane (2) were obtained from the fibrous roots of Anemarrhena asphodeloides Bge. Their structures were determined by comprehensive 1D, 2D NMR and HRESIMS data. By comparing the calculated ECD curves and OR with the experimental data the absolute configurations were determined. The antitumor activity of all isolates was evaluated against two human hepatoma carcinoma cells (HepG2 and Hep3B) in vitro. The results demonstrated that compound 1 and 2 showed potent cytotoxicity against HepG2 and Hep3B cells.

Keywords:

• Benzophenone
• 1,3-diphenylpropane
• Anemarrhena asphodeloides Bge.
• cytotoxicity

Acknowledgements

We thank the professor Shao-jiang Song and his group from Shenyang Pharmaceutical University for all spectra tests. In addition, Zhen-Dong Liao wants to thank Fang-Fang Chen for your care and support. Will you marry me?

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by Anhui University Natural Science Major Research Project (No: KJ2018ZD030) and Anhui University Natural Science Key Research Project (No: KJ2018A0298).