New α-ditetralonyl glucoside from the green walnut husk of Juglans mandshurica

Abstract

One new α-ditetralonyl glucoside (1), was isolated from the green walnut husk of Juglans mandshurica (Juglandaceae), together with twelve known compounds (2–13). The structure of the new compound was determined as (2R,4S,10S,12S)-2-[7-(12,13,16-trihydroxy-α-tetralonyl-13-O-β-D-glucopyranoside)]- 4,8-dihydroxy-α-tetralone-4-O-β-D-glucopyranoside (1), on the basis of detailed spectroscopic analyses, and acidic hydrolysis. Compounds 6, 7 and 11 were isolated from the genus Juglans for the first time. Compound 1–13 showed weak cytotoxic against A549 and HeLa cell lines.

Graphical Abstract

Keywords:

• Juglans mandshurica
• Juglandaceae
• α-ditetralonyl glucoside
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the general project of department of education of Liaoning Province (grant no 201610163L13) and the Natural Science Foundation of Liaoning Province (grant no 201602712).