Determination of natural phenolic compounds of Ferula longipedunculata Peşmen and assessment their antioxidant and anticholinesterase potentials

Abstract

The paper reports anticholinesterase and antioxidant activities of extracts, fractions from aerial parts, roots, flowers, fruits of Ferula longipedunculata Peşmen (Apiaceae). Phenolic content, antioxidant activities of samples were carried out using Folin-Ciocalteu, DPPH, TBA methods. Anticholinesterase activity was actualised through Ellman’s method. The utmost and least total phenolic content were detected in root MeOH extract (36.4 mg GAE g⁻¹ DW) and aerial part (23.74 mg GAE g⁻¹ DW), respectively. Hexane fraction of root exhibited significant inhibition against AChE (37.99%) and BuChE (81.66%) at 20 μg/mL as well as remarkable antioxidant and anticholinesterase activities. However, investigations on roots will be substantial for improved usage of F. longipedunculata for pharmaceutical and food search needs.

Graphical Abstract

Keywords:

• Antioxidants: anticholinesterase
• Apiaceae
• Ferula longipedunculata
• phenolics