Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 10
Submit an article Journal homepage
165
Views
8
CrossRef citations to date
0
Altmetric
Short Communications

Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes

Tais Susane Pereiraa Departamento de Biotecnology, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, BrazilView further author information
,
Giovana Natiele Machado Esquissatoa Departamento de Biotecnology, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, BrazilView further author information
,
Emmanoel Vilaça Costab Departamento de Química, Universidade Federal do Amazonas, Manaus, AM, BrazilView further author information
,
Paulo Cesar de Lima Nogueirac Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilView further author information
&
Marialba Avezum Alves de Castro-Pradoa Departamento de Biotecnology, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, BrazilCorrespondence[email protected]
View further author information
Pages 1682-1685 | Received 25 Feb 2019, Accepted 21 May 2019, Published online: 14 Jun 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Hydro-distilled essential oil from leaves of Xylopia laevigata was characterized by GC-MS. Twenty-seven components were identified and the oil’s major constituents comprised germacrene D, bicyclogermacrene, (E)-caryophyllene and germacrene B. The cytotoxicity of the essential oil of X. laevigata (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all tested concentrations. Cultures treated with EOXL demonstrated significant increase in the frequencies of micronuclei in the cytokinesis-block micronucleus assay (CBMN) and reduction of the cytokinesis-block proliferation index (CBPI) rates. Results demonstrated the cytostatic and mutagenic effects of EOXL, the latter for the first time.

Graphical Abstract

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This work was supported by CAPES and FAPITEC/SE.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Kundmannia sicula (L.) DC: a rich source of germacrene D
Source: Informa UK Limited
Use of the alkaline comet assay for industrial genotoxicity screening
Source: Elsevier BV
Biological activities of the essential oil from the leaves ofXylopia laevigata(Annonaceae)
Source: Informa UK Limited
Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves ofXylopia laevigatain Experimental Models
Source: Hindawi Limited
Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity
Source: Elsevier BV
Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes
Source: Figshare
Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test
Source: Elsevier BV
Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?
Source: Hindawi Limited
Genoprotective effects ofOriganum vulgareethanolic extract against cyclophosphamide-induced genotoxicity in mouse bone marrow cells
Source: Informa UK Limited
Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes
Source: Figshare
Oxidative stress and cancer; the role of hesperidin, a citrus natural bioflavonoid, as a cancer chemoprotective agent
Source: Informa UK Limited
The radioprotective effects of Origanum vulgare extract against genotoxicity induced by (131)I in human blood lymphocyte.
Source: Mary Ann Liebert Inc
Chemical Constituents and Anticancer Effects of the Essential Oil from Leaves of Xylopia laevigata
Source: Georg Thieme Verlag KG
ANTICANCER ACTIVITIES OF ESSENTIAL OILS IN CANCER THERAPY
Source: Wiley
Biological effects of essential oils - A review
Source: Elsevier BV

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.