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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 10
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Research Articles

Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity

Akash R. Gohila Natural Products Microbiology, Piramal Enterprises Limited, Mumbai, India;b Natural Products Bioactivity Lab, Piramal Enterprises Limited, Mumbai, IndiaView further author information
,
Sunil K. Deshmukha Natural Products Microbiology, Piramal Enterprises Limited, Mumbai, IndiaORCID Iconhttps://orcid.org/0000-0001-5395-9512View further author information
ORCID Icon,
Vaishali Bhattacharyac High Throughput Screening, Piramal Enterprises Limited, Mumbai, IndiaView further author information
,
Rahul Lavhaleb Natural Products Bioactivity Lab, Piramal Enterprises Limited, Mumbai, IndiaView further author information
,
Shilpa Verekara Natural Products Microbiology, Piramal Enterprises Limited, Mumbai, IndiaView further author information
&
Abhijeet S. Kateb Natural Products Bioactivity Lab, Piramal Enterprises Limited, Mumbai, India;d National Institute of Pharmaceutical Education and Research - Ahmedabad, Gandhinagar, Gujarat, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0500-488XView further author information
ORCID Icon
Pages 1573-1581 | Received 24 Feb 2019, Accepted 19 May 2019, Published online: 06 Jun 2019
 
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Abstract

Chemical characterization of ethyl acetate extract of Exophiala sp. has afforded the isolation of three compounds including a new isocoumarin named exophiarin (1). Exophiala sp. was obtained from the soil containing dumped organic waste (litter). Initially, LC-UV-MS analysis of the extract of Exophiala sp. revealed the presence of a new compound having molecular weight 438 (1) and previously reported TPI-2 and TPI-5. The novelty was established using advanced database search comprising of biological source, molecular weight and UV profile. 1D, 2D NMR and HRMS data have been used for structure elucidation. Exophiarin with TPI-2 and TPI-5 have displayed moderate improvement in glucose uptake activity when tested in rat skeletal muscle cell line L6.

Graphical Abstract

Acknowledgement

We acknowledge Rajendra Kshirsagar, Piramal Enterprises Limited for NMR support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Funding was provided by Piramal Enterprises Limited, Mumbai.

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