Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans

Abstract

Three new sesquiterpene quinones/hydroquinones, 20-demethoxy-20-isopentylaminodactyloquinone D (1), 20-demethoxy-20-isobutylaminodactyloquinone D (2), and 19-methoxy-dictyoceratin-A (3), and five known related compounds (4−8) were isolated from the marine sponge Dactylospongia elegans. Their structures were elucidated by spectroscopic analysis, ECD calculation, single-crystal X-ray diffraction, and comparison with the literature. Compounds 3 and 5−8 exhibited activities against the human cancer cell lines DU145, SW1990, Huh7, and PANC-1 with IC₅₀ values ranging from 2.33 to 37.85 μM.

GRAPHICAL ABSTRACT

Keywords:

• Dactylospongia elegans
• meroterpenoid
• cytotoxic activity

Additional information

Funding

This research was supported by the National Key Research and Development Program of China (No. 2018YFC0310900), the National Natural Science Foundation of China (Nos. U1605221, 41576130, 81602982, 41606173 and 81703624), the International Postdoctoral Exchange Fellowship Program (No. 20170092), Shanghai Rising-Star Program (19QA1405300), Shanghai Municipal Health Commission Excellent Young Talent Program (No. 2018YQ28).