Chemical constituents from the fruits of Cullen corylifolium (L.) Medik. by the targeted separation mode

Abstract

Two new compounds, corylifol H (1) and epi-bavacoumestan C (2), together with a new natural product named 8-geranyl daidzein (3), were isolated from the fruits of Cullen corylifolium (L.) Medik. (syn. of Psoralea corylifolia L.) by the targeted separation mode. The structures of these compounds were elucidated on the basis of spectroscopic methods and by comparison with literature properties. The anti-inflammatory effects of the two new compounds were also evaluated by activity assay in vitro. The results showed that compounds 1 and 2 inhibited nitric oxide production in LPS-activated RAW 264.7 macrophages in a dose dependent manner.

Graphical Abstract

Keywords:

• Cullen corylifolium
• Psoralea corylifolia
• corylifol H
• epi-bavacoumestan C
• targeted separation mode
• anti-inflammatory effect

Acknowledgements

The authors thank Prof. Tian-Xiang Li for authenticating the plant material and Harmonia Testing Technology (Tianjin, China) Limited Company for NMR measurements.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Basic Scientific and Technological Project (2014FY111100), Tianjin Support Plans for the Top of the Notch Youth Talents, and TCM Standardization Project Supported by State Administration of Traditional Chinese Medicine (ZYBZH-C-JX-38).