A new cardenolide glycoside from the roots of Streptocaulon juventas (lour.) merr. (Asclepiadaceae)

Abstract

From remaining aqueous fraction of the roots of Streptocaulon juventas, one new cardiac glycoside named periplogenin 3-O-β-gentiobioside (1) together with six known ones (2–7) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Compound 1 showed moderate cytotoxicity against non-small cell lung carcinoma NCI-H460 and ovarian cancer HeLa cells. Moreover, compounds 2 and 3 exhibited remarkable cytotoxicity against NCI-H460 cell with the IC₅₀ values of 0.34 and 0.068 μM, respectively.

Keywords:

• Streptocaulon juventas
• Asclepiadaceae
• cardiac diglycoside
• cytotoxicity

Supplementary material

NMR and MS spectra for the new compound 1.

Disclosure statement

No potential conflict of interest was reported by the authors.