Phenolic constituents from the fresh pericarps of Juglans sigillata

Abstract

Three new phenolic compounds, 2,3,4-trihydroxy-1-(4′-hydroxybenzyl)benzoic acid (1), 2,3,4-trihydroxy-1-(4′-hydroxy-3′-methoxybenzyl)benzoic acid (2), and 2-(4′-hydroxy-3′-methoxybenzyl)-3,5-dimethoxy-1,4-benzoquinone (3), were isolated from the fresh pericarps of Juglans sigillata Dode. Their structures were elucidated by integrated spectroscopic techniques. Bioactivity screening results showed that compounds 1–3 exhibited moderate neuroprotective effects against H₂O₂-induced or CoCl₂-induced cellular damage in human neuroblastoma SH-SY5Y cell line.

Graphical Abstract

Keywords:

• Juglans sigillata Dode
• Juglandaceae
• phenolic constituents
• neuroprotective effects

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project was supported financially by the Natural Science Foundation of China (No. 21572073, 31770380 and 31270394). We are grateful to the staff at the Analytical and Testing Center of Huazhong University of Science and Technology for collecting the spectroscopic data.