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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 8
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Research Article

Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia

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Pages 1256-1261 | Received 05 Jun 2019, Accepted 13 Jul 2019, Published online: 22 Jul 2019
 

Abstract

Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds (1–5) towards three human cancer cells (HeLa, MCF-7, P-388), compounds 1, 4 and 5 showed very potent activity against Hela cells with IC50 values 2.6; 0.8; 1.1 μM, respectively.

Graphical Abstract

Acknowledgments

Universitas Airlangga, Surabaya, Indonesia supported this work, through Penelitian Disertasi Doktor grant 2019.

Disclosure statement

No potential conflict of interest reported by the authors.

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