Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities

Abstract

Terminaliamide (1), a new ceramide was isolated from the roots of Terminalia mantaly H. Perrier (Combretaceae) along with 4 known compounds (2–5). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound 1 exhibited moderated antibacterial activity towards Staphylococcus aureus with MIC value of 62.5 μg/mL. The crude MeOH extract (TMr) highly reduced Plasmodium falciparum growth with an IC₅₀ value of 10.11 μg/mL, while hexane fraction (F1) highly reduced Trypanosoma brucei brucei growth with an IC₅₀ value of 5.60 µg/mL. All tested samples presented little or no in vitro cytotoxicity on HeLa cell line. The present work confirms that T. mantaly is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.

Graphical Abstract

Keywords:

• Terminalia mantaly
• Terminaliamide
• antimicrobial
• antiplasmodial
• antitrypanosomal
• cytotoxicity

Acknowledgments

The authors are grateful to Mr Victor Nana (National Herbarium of Cameroon) for the botanical identification, to Michelle Issac for her contribution on antimalarial, antirypanosomal and cytotoxic assays, and, to Marc Parmart for polarimeter and boiling point equipment.

Disclosure statement

No potential conflict of interest was reported by the authors.