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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 8
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Short Communication

Phenolic glycosides from Nitraria sibirica leaves and their in vitro biological activities

, , , ORCID Icon & ORCID Icon
Pages 1388-1392 | Received 22 May 2019, Accepted 18 Jul 2019, Published online: 05 Aug 2019
 

Abstract

Seventeen phenolic glycosides were isolated from the Nitraria sibirica. Their structures were identified by the spectroscopic data and comparison with literatures as isovanillyl alcohol-7-O-β-d-glucopyranoside (1), benzyl β-primeveroside (2), benzyl-O-β-d-glucopyranoside (3), 1-O-β-d-glucopyranosyl-4-(8-hydroxyethyl)-2-methoxyphenyl (4), dehydrosyringin (5), trans-ferulic acid-4-O-β-d-glucoside (6), cis-ferulic acid 4-O-β-d-glucopyranoside (7), glucosyringic acid (8), 1-O-feruloyl-β-d-glucoside (9), sachaloside VII (10), (3S, 5R, 6R, 7E, 9S)-megastigmane-7-ene-3-hydroxy-5,6-epoxy-9-O-β-d-glucopyranoside(11), 3-hydroxy-4,5-dimethoxybenzyl alcohol (12), pinoresinol 4-O-β-d-glucopyranoside (13), eucommin A (14), isoeucommin A (15), acanthoside (16), liriodendrin (17). All these compounds except compound 13 were isolated from the Nitraria genus for the first time. In bioactivity assays for all compounds, the compounds 8 and 15 were exhibited strong antioxidant activity (IC50 = 18.11 and 16.29 μM respectively), while compounds 3 and 11 were exhibited strong PTP1B enzymatic inhibition (IC50 = 6.97 and 11.76 μM, respectively). Furthermore, the compounds 10 and 17 were presented strong inhibitory capacities against Candida albicans (14.5 and 13.5 mm, respectively).

Acknowledgements

We thank Dr. Jun Li for her valuable comments on our manuscript. The work was financially supported by the Natural Science Foundation of Xinjiang (China) (Grant No. 2016D01A071). We thank the Central Asian Drug Discovery and Development Center of the Chinese Academy of Sciences for support of our research.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Natural Science Foundation of Xinjiang, China (Grant no. 2016D01A071).

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