Sesquiterpenoids from Saussurea costus

Abstract

Sixteen sesquiterpenoids (1 – 16), including two new compounds namely saussucostusosides A and B (1 and 2), were isolated from the roots of Saussurea costus by various chromatographic separations. Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among isolated compounds, costunlide (6), 3β-[4-hydroxymethacryloyloxy]-8α-hydroxycostunolide (10) and 11β,13-dihydrozaluzanin C (16) exhibited potent inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC₅₀ values of 7.08 ± 0.34, 2.40 ± 0.06 and 5.55 ± 0.24 µM, respectively.

Graphical Abstract

Keywords:

• Saussurea costus
• Asteraceae
• sesquiterpenoid
• NO production

Acknowledgements

The authors are thankful to the Institute of Chemistry, VAST for measurement of the NMR spectra and Dr. Bui Huu Tai, Institute of Marine Biochemistry, VAST for measurement of the HR-QTOF mass spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by a grant from Vietnam Academy of Science and Technology (code: KHCBHH.02/18-20).