Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer

Abstract

Three new phenolic glycosides, intermedia A–C (1–3), one new acyclic alcohol glycoside, intermedia D (4), together with 3 known glycosides (5–7), were isolated from the dried roots of Paeonia intermedia C. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compound 1 have a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compound 3 exhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an IC₅₀ value of 85.76 ± 1.36 μM.

Graphical Abstract

Keywords:

• Paeonia intermedia C. A. Meyer
• phenolic glycoside
• acyclic alcohol glycoside
• anti-inflammatory activity

Acknowledgments

We thank Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University for the HRESIMS measurement.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81603275) and the China Postdoctoral Science Foundation (Grant No. 2016M602697, No. 2018T110988).