Modulation of the 5-HT₃A receptor current by desacylbaldrinal

Abstract

The serotonin (5-hydroxytryptamine) type 3 receptor is an important target in the control of digestive dysfunction such as anorexia and bulimia, and 5-HT₃ receptor antagonists are effective against eating disorder and the early-phase chemotherapy and radiotherapy evoked vomiting. Our previous research of Valeriana jatamansi revealed the presence of iridoids, which showed potent antitumor activities. Here, we explored the effects of 10π aromatic iridoid desacylbaldrinal isolated from V. jatamansi on the 5-HT₃ receptor current. We performed whole cell recordings of 5-HT₃A receptor currents in the presence of the compound. The result indicated that desacylbaldrinal inhibited the 5-HT-mediated 5-HT₃A receptor current.

Graphical abstract

Keywords:

• Valeriana jatamansi
• desacylbaldrinal
• 5-HT3A

Acknowledgement

The authors thank Dr. Ying-Ji Li (ICE Bioscience INC., Beijing, China) for their excellent help with electrophysiology experiments and Qiong Gu (Sun Yat-Sen University., Guangdong, China) for target prediction.

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [No.81703693], project funded by China Postdoctoral Science Foundation [No.2019M653363], the Fund Project of Science and Technology of Sichuan [No.2016TD0006. No.2019052] and Chengdu Municipal Science and Technology Foundation [No.2016-HM01-00457-SF].