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Abstract
New chymotrypsin inhibitory peptides named streptopeptolins B and C were isolated from Streptomyces olivochromogenes. Structures of streptopeptolins B and C were determined to be cyclic depsipeptides possessing 3-amino-6-hydroxy-2-piperidone unit by interpretation of NMR spectra and ESI-MS. Streptopeptolins B and C showed inhibitory activities to chymotrypsin with IC50 of 8.0 and 12.0 μg/mL, respectively.
GRAPHICAL ABSTRACT
Acknowledgments
The NMR spectra were recorded on Bruker Avance 600 and Avance III HD 800 spectrometers at the Advanced Analysis Center, NARO.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by the Japan Society for the Promotion of Science by Grants-in-aids (grant number 16K01913).
