New diterpenoids from the rhizomes of Hedychium forrestii

Abstract

A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambiguously established by means of extensive spectroscopic data (IR, UV, HRMS, and NMR) and electronic circular dichroism (ECD) calculations. This is the first report of naturally occurring labdane-type hexanorditerpenoid. Compound 1 was proved to have moderate cytotoxicity against XWLC-05 cell line with an IC₅₀ value of 53.6 μM.

Graphical Abstract

Keywords:

• Hedychium forrestii
• hexanorditerpenoid
• hedychins C and D
• cytotoxicity

Acknowledgements

The authors are also grateful to Prof. Xiao-Qiong He (Kunming Medical University) for cytotoxic screening. The authors are also grateful to Kunming Institute of Botany, Chinese Academy of Sciences, for measuring IR, UV, HRMS, and NMR data, respectively.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (Nos. 81460533, 81060262 and 21662048), the Yunnan Provincial Science and Technology Department-Applied Basic Research Joint Special Funds of Yunnan University of Traditional Chinese Medicine (2017FF116 (-011)), and the NSFC—Joint Foundation of Yunnan Province (U1802287).