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Volume 35, 2021 - Issue 15
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A new phenolic acid from the wood of Mangifera gedebe

Hai Xuan Nguyena Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamORCID Iconhttps://orcid.org/0000-0001-8447-8367View further author information
ORCID Icon,
Loc Thanh Nguyena Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamView further author information
,
Truong Nhat Van Doa Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamView further author information
,
Tho Huu Lea Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamView further author information
,
Phu Hoang Danga Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamORCID Iconhttps://orcid.org/0000-0002-4989-9315View further author information
ORCID Icon,
Hung Manh Trana Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, VietnamView further author information
,
Nhan Trung Nguyena Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, Vietnam;b Cancer Research Laboratory, VNUHCM–University of Science, Hochiminh City, VietnamView further author information
&
Mai Thanh Thi Nguyena Faculty of Chemistry, VNUHCM–University of Science, Hochiminh City, Vietnam;b Cancer Research Laboratory, VNUHCM–University of Science, Hochiminh City, VietnamCorrespondence[email protected]
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Pages 2579-2582 | Received 24 Apr 2019, Accepted 07 Oct 2019, Published online: 23 Oct 2019
 
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Abstract

From the methanol extract of the wood of Mangifera gedebe (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid (1) and six known compounds (2–7). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for α-glucosidase inhibitory activity. Compounds 4–7 showed more potent inhibitory activity, with IC50 values ranging from 45.3 to 142.6 μM, than that of a positive control acarbose (IC50, 214.5 μM).

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Disclosure statement

No potential conflict of interest was reported by authors.

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Funding

This research was supported by a grant from the Vietnam National University-Hochiminh City (No. C2018-18-07) to H.X.N.

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A new phenolic acid from the wood of Mangifera gedebe
Source: Taylor & Francis
A new phenolic acid from the wood of Mangifera gedebe
Source: Taylor & Francis

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