Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 18
Submit an article Journal homepage
620
Views
12
CrossRef citations to date
0
Altmetric
Short Communications

A new antimicrobial indoloditerpene from a marine-sourced fungus aspergillus versicolor ZZ761

Di ZhangOcean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. ChinaView further author information
,
Wenwen YiOcean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. ChinaView further author information
,
Hengju GeOcean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. ChinaView further author information
,
Zhizhen ZhangOcean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. ChinaCorrespondence[email protected] [email protected]
View further author information
&
Bin WuOcean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. ChinaCorrespondence[email protected] [email protected]
View further author information
Pages 3114-3119 | Received 23 Aug 2019, Accepted 10 Oct 2019, Published online: 05 Nov 2019
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

A new indoloditerpene (1) and fifteen known compounds (2–16) were isolated from a marine-derived fungus Aspergillus versicolor ZZ761. Structure of the new compound was elucidated as (3 R,9S,12R,13S,17S,18S)-2-carbonyl-3-hydroxylemeniveol based on its HRESIMS data, NMR spectroscopic analyses, the Mosher′s method, and ECD calculation. This new indoloditerpene (1) showed antimicrobial activities with MIC values of 20.6 μM against Escherichia coli and 22.8 μM against Candida albicans. Diorcinol (2) and versicolorin B (6) had activities in inhibiting the proliferation of human glioma U87MG and U251 cells with IC50 values of 4.4 and 6.2 μM and 11.3 and 30.5 μM, respectively.

Graphical Abstract

Supplementary material

The experimental section, HRESIMS, NMR, IR, and UV spectra of 1 as well as 13C and 1H NMR data of compounds 1–16 are available in the Supplementary Material.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the National Key R&D Program of China (No. 2018YFC0311002) and the National Natural Science Foundation of China (No. 81773587).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets
Source: Oxford University Press (OUP)
A new curvularin glycoside and its cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7.
Source: Informa UK Limited
The structures of five diketopiperazines from Aspergillus ustus
Source: Elsevier BV
Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Fungus Aspergillus amoenus: Biogenetic Implications
Source: American Chemical Society (ACS)
Structures of a New Type of Indoloditerpene, Petromindole, and a New Asterriquinone Derivative, PM-53, from the Ascostromata of Petromyces muricatus
Source: Pharmaceutical Society of Japan
Isolation and structure of nodulisporic acid A1 and A2, novel insecticides from a Nodulisporium sp.
Source: Elsevier BV
Isolation and Structures of Two New Indoloditerpenes Related to Aflavinine from a Microsclerotium-Producing Strain of Aspergillus flavus
Source: Pharmaceutical Society of Japan
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III: Production, isolation and structure elucidation of new components
Source: Japan Antibiotics Research Association
Speramides A-B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007
Source: Elsevier BV
Three xanthones from a marine-derived mangrove endophytic fungus
Source: Springer Science and Business Media LLC
Three New Types of Indoloditerpenes, Emindole PA—PC, from Emericella purpurea. Revision of the Structure of Emindole PA.
Source: Wiley
New mycotoxins from the scale insect fungus Aschersonia coffeae Henn. BCC 28712
Source: Elsevier BV
Structure of demethylsterigmatocystin
Source: International Union of Crystallography (IUCr)
A New Azaphilone, Falconensin H, from Emericella falconensis
Source: Pharmaceutical Society of Japan
New nematotoxic indoloditerpenoid produced by Gymnoascus reessii za-130.
Source: American Chemical Society (ACS)
Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp.
Source: American Chemical Society (ACS)
Emeniveol; A new pollen growth inhibitor from the fungus, Emericella nivea
Source: Elsevier BV
Indole-Diterpenoids with Anti-H1N1 Activity from the Aciduric Fungus Penicillium camemberti OUCMDZ-1492
Source: (:unav)
Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp
Source: American Chemical Society (ACS)
Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities
Source: Elsevier BV

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.