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Abstract
One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3–5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of 1 was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 7 showed significant ability of the inhibition of spermatozoa to fertilize egg-cells of the sea urchin Strongylocentrotus intermedius with IC50 value 21 µM.
Acknowledgements
The study was carried out using the equipment and resources of the Collective Facilities Center ‘The Far Eastern Center for Structural Molecular Research (NMR/MS) PIBOC FEB RAS’ and the Collective Facilities Center ‘Collection of Marine Microorganisms PIBOC FEB RAS’.
