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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 18
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Short Communications

A new monoterpene-lactone with neuroprotective activity from corn silk

Wei-Yu Zhoua Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Tian-Ming Lva Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Zi-Lin Houa Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Ming Baia Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Bin Linb School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaView further author information
,
Xiao-Xiao Huanga Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
View further author information
&
Shao-Jiang Songa Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
 show all
Pages 3142-3145 | Received 20 Sep 2019, Accepted 29 Oct 2019, Published online: 11 Nov 2019
 
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Abstract

A new monoterpene-lactone (1) along with five known compounds (2–6) were isolated from corn silk. The structure of the new compound was elucidated based on comprehensive spectroscopic analyses and quantum chemical calculations of electronic circular dichroism (ECD) curves. All compounds were evaluated for their neuroprotective effects against H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). As a result, compound 1 exhibited weak neuroprotective activity.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).

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