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Research Articles

A new dammarane type triterpene glucoside from the aerial parts of Gouania longipetala (Rhamnaceae)

Soh Désiréa Department of Chemistry, Higher Teacher Training College, TWAS Research Unit (TRU), University of Bamenda, Bamenda, Cameroon;b Laboratory of Medicinal Chemistry & Pharmacognosy, Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon;c H. E. J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences (ICCBS), University of Karachi, Karachi, PakistanCorrespondence[email protected]@yahoo.fr
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,
Nkwengoua Ernestineb Laboratory of Medicinal Chemistry & Pharmacognosy, Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, CameroonView further author information
,
Tchebemou Bakang Brunob Laboratory of Medicinal Chemistry & Pharmacognosy, Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, CameroonView further author information
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Sidjui Sidjui Lazarec H. E. J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan;d Faculty of Sciences, Department of Organic Chemistry, Institute of Medical Research and Medicinal Plant Studies, TWAS Research Unit (TRU), University of Yaounde I, Yaoundé, CameroonView further author information
,
Dzo Defokou Ulrichb Laboratory of Medicinal Chemistry & Pharmacognosy, Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, CameroonView further author information
,
Mehreen Lateefe Multidisciplinary Research Lab, Bahria University Medical and Dental College, Karachi, PakistanView further author information
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Bernd Schneiderf Max Planck Institute for Chemical Ecology, Jena, GermanyView further author information
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Muhammad Shaiq Alic H. E. J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences (ICCBS), University of Karachi, Karachi, PakistanView further author information
&
Nyassé Barthélemyb Laboratory of Medicinal Chemistry & Pharmacognosy, Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, CameroonView further author information
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Pages 3192-3203 | Received 22 Apr 2019, Accepted 03 Nov 2019, Published online: 29 Nov 2019
 
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Abstract

3-O-β-D-glucopyranosyl gouanogenin A (1), a new naturally occurring dammarane class of triterpene glucoside, has been isolated from the aerial parts of Gouania longipetala along with six known secondary metabolites 2–7. Their structure was elucidated through spectroscopic data including 1 D- and 2 D-NMR. The compounds 1 and 6 showed significant antioxidant potential in DPPH radical scavenging assay. On the other hand, the compound 4 revealed potent inhibitory potential against the enzyme urease, while 1 and 3 were significantly active.

Acknowledgements

The author SD are grateful to the Third World Academy of Sciences (TWAS) and The International Centre for Chemical and Biological Sciences for the award of ICCBS-TWAS fellowship 2016 (Fr. 3240293185) and wish to thank Dr Tacham Walters for his assistance in the collection and identification of plant samples.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Third World Academy of Sciences (TWAS) and The International Center for Chemical and Biological Sciences for the award of ICCBS-TWAS fellowship 2016.

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