https://orcid.org/0000-0002-7759-9694
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Abstract
The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).
Graphical Abstract
Disclosure statement
The authors confirm that this article content has no conflict of interest.
Additional information
Funding
To FAPEMIG Process APQ-01410-14 for financial support to ABO. To CNPq Process 440911/2016, Capes Process 2058/2016 and DECIT/MS for financial support to EGK. To CNPq for scholarship to MLS and fellowship to ABO.
