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Abstract
A new phenylpentenol, wortmannine H (1) was isolated from Talaromyces wortmannii LGT-4, an endophytic fungus of Tripterygium wilfordii. The structure of 1 was elucidated by IR, MS, 1D and 2D NMR spectra and comparison of the experimental and calculated optical rotatory dispersion (ORD). Monoamine oxidase (MAO), acetylcholinesterase (AChE) and phosphoinositide 3-kinase (PI3Kα) inhibitory activities of 1 was also tested. The compound did not show good biological activity.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China under Grant [No. 21762027] and Leading Academic Discipline Project of Lanzhou University of Technology under Grant [2018].
