A new triterpenoid and other constituents with cytotoxic activity from the roots of Sanguisorba officinalis L

Abstract

Sanguisorba officinalis L. is a traditional herbal plant that belongs to the genus Sanguisorba and the family Rosaceae. A new ursane-type triterpenoid, 3-oxo-urs-11, 13(18)-dien-19, 28-olide (1), two known ursane-type triterpenoids (3 − 4) and three known oleanane-type triterpenoids (2, 5 − 6) were isolated from the roots of S. officinalis by silica gel column and MPLC. Their structures were identified by interpretation of spectroscopic data (1 D NMR, 2 D NMR, HR-ESI-MS) and comparison with those reported in the literature. Compound 2 was isolated from the Rosaceae family, compounds 3–5 were obtained from the genus Sanguisorba, and compound 6 was obtained from the S. officinalis for the first time. Additionally, all of the isolated compounds were evaluated for their cytotoxic activity against three human cancer cells. Compound 3 showed better cytotoxic activity against A549, HeLa, SK-Hep1 cells than the other compounds with IC₅₀ values of 48.58 ± 1.88, 47.84 ± 2.01, 42.31 ± 2.43 μM, respectively.

Graphical Abstract

Keywords:

• Sanguisorba officinalis L.
• ursane-type triterpenoid
• oleanane-type triterpenoid
• cytotoxic activity

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China (No. 81760627, 81660699, and 81660579). We thank Louise Adam, ELS(D), from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac. . . . . . . . . . ) for editing the English text of a draft of this manuscript.