Two new isoquinoline alkaloids from the seeds of Nandina domestica

Abstract

Two new isoquinoline alkaloids, 6 R,6aS-N-nantenine N_β-oxide (1), 6S,6aS-N-nantenine N_α-oxide (2), along with nine known alkaloids, nantenine (3), oxonantenine (4), protopine (5), nornantenine (6), N-methyl-laurotetanine (7), isocorydine (8), O-methyflavinantine (9), N-methyl-2,3,6-trimethoxymorphinan-dien-7-one N_β-oxide (10) and (+)-10-O-methylhernovine N_β-oxide (11) were isolated from the seeds of Nandina domestica. Their structures were elucidated by extensive analyses of spectroscopic data (IR, UV, HRESIMS, 1 D and 2 D NMR), ECD calculation and comparison with the related literatures. In addition, the cytotoxicity against A549 cells of these alkaloids was determined by the MTT assay.

Graphical Abstract

Keywords:

• Nandina domestica
• isoquinoline alkaloid
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from the National Key R&D Program of China (No. 2017YFC1703800), National Natural Science Foundations of China (Nos. 81973190, 81803376, 81703662), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y036), Science and Technology Planning Project of Guangzhou City (Nos. 201904010447, 201707010399), Natural Science Foundation of Guangdong Province (Nos. 2018B030311020, 2017A030313732), China Postdoctoral Science Foundation (No. 2019T120795).