https://orcid.org/0000-0001-5622-7333
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Abstract
One new aromatic bisabolene-type sesquiterpenoid (1), along with four known analogues (2–5) were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. Their structures were elucidated by NMR, HRESIMS, X-ray crystallographic analysis, and quantum chemical ECD calculations as well as comparison of those data with literature data. Compounds 1–5 were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2 and 5 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Aeromonas hydrophilia, Escherichia coli, Edwardsiella tarda and Vibrio harveyi, with the MIC values ranging from 1.0 to 8.0 μg/mL.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This research work was financially supported by the Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology (2016ASKJ14), and the National Natural Science Foundation of China (31700043 and 81600672), and the Key Research and Development Program of Shandong Province (2019GSF107091). X.-D. Li and X. Li appreciate the China Postdoctoral Science Foundation (2016LH00033, 2017M612358, and 2017M612360) for project funding. B.-G. Wang acknowledges the support of the Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences (KEXUE2018G28) and the Taishan Scholar Project from Shandong Province. X. Li appreciate the Shandong Provincial Natural Science Foundation (ZR2017BB073).
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.
