Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 19
Submit an article Journal homepage
159
Views
6
CrossRef citations to date
0
Altmetric
Short Communications

Diarylpentanones from the root of Wikstroemia indica and their cytotoxic activity against human lung A549 cells

Zhihui Liua School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Mengyu Donga School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Xiangyang Qiua School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Na Hana School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
&
Jun Yina School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected] [email protected]
Pages 3346-3349 | Received 08 Oct 2019, Accepted 18 Nov 2019, Published online: 09 Dec 2019
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

One new diarylpentanone, 4(S)-hydroxy-1, 5-diphenyl -2(E)-en-1-pentanone (1), two diarylpentanones isolated from Wikstroemia indica for the first time (3 and 5) and two other known diarylpentanones were isolated from petroleum ether fraction of root of Wikstroemia indica. The structure of the new compound including absolute configuration was elucidated by extensive spectroscopic techniques, including 1D, 2D NMR, HR-ESI-MS and ECD spectroscopy. All isolated compounds were tested for their cytotoxic activity against cancer-derived cell lines A549. Compound 5 exhibited remarkable cytotoxic activity comparable to that of positive control cisplatin.

Graphical Abstract

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.
Source: Georg Thieme Verlag KG
Oleodaphnoic acid and coriaceol, two new natural products from the stem bark of Wikstroemia coriacea.
Source: HAL CCSD
Diarylpentanoids from Diplomorpha canescens and Diplomorpha ganpi
Source: Elsevier BV
In vitro antimalarial activity of biflavonoids from Wikstroemia indica.
Source: Georg Thieme Verlag KG
Extraction optimisation of daphnoretin from root bark of Wikstroemia indica (L.) C.A. and its anti-tumour activity tests
Source: Elsevier BV
Chemical Constituents of Daphne giraldii Nitsche
Source: Wiley
(+)-Arctigenin, a lignan from Wikstroemia indica
Source: Elsevier BV
A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica.
Source: Informa UK Limited
A new coumarin from Wikstroemia indica (L.) C. A. Mey
Source: Elsevier BV
Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells.
Source: Elsevier BV
Bioactive components and pharmacological action of Wikstroemia indica (L.) C. A. Mey and its clinical application.
Source: Bentham Science Publishers Ltd.
Phenols from the rhizome of Wikstroemia indica
Source: Elsevier BV
Sikokianin A from Wikstroemia indica protects PC12 cells against OGD/R-induced injury via inhibiting oxidative stress and activating Nrf2
Source: Taylor & Francis

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.