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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 20
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Research Articles

Chemical constituents of Trillium tschonoskii Maxim.

Ting YanSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Anhua WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaORCID Iconhttps://orcid.org/0000-0002-8615-3424
ORCID Icon,
Gaosheng HuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
&
Jingming JiaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0779-4013
ORCID Icon
Pages 3351-3359 | Received 26 Jun 2019, Accepted 25 Nov 2019, Published online: 13 Jan 2020
 
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Abstract

A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium tschonoskii Maxim. The structure of isolated compounds was elucidated by spectroscopic analysis. Compound 1–6 were assessed for their cytotoxicity against cancer cell lines (MCF-7, HCT-116, DU-145, SGC-7901, MCF-7/ADR, K562/ADR), and the result showed that compound 4 was highly toxic to six human tumor cell lines.

Graphical Abstract

Acknowledgments

The work was supported by National Natural Science Foundation of China (NO. 81473423) and Liaoning Provincial Department of Education(2019LJC09).

Disclosure statement

The authors declare that there are no conflicting interest.

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