Antiinflammatory lanostane triterpenoids from Ganoderma lucidum

Abstract

Phytochemical and biological studies of the methanolic extracts from Ganoderma lucidum (Polyporaceae) have led to the identification and isolation of a new lanostane triterpenoid, ganosidone A (1), and its eight known derivatives (2‒9). The structure of new compound was determined by HREIMS, 1 D and 2 D NMR experiments and by comparing the acquired physicochemical data with the published values. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharides (LPS) in mouse macrophage RAW 264.7 cells in vitro. Notably, at a concentration of 50 μM, compounds 4 and 7 inhibited NO production by 86.5% and 88.2%, respectively.

Graphical Abstract

Keywords:

• Ganoderma lucidum
• polyporaceae
• lanostane triterpenoid
• inhibit nitric oxide production

Acknowledgments

We thank H. S. Shin, National Center for Inter University Research Facilities, Seoul National University, for the provision of the NMR and Mass Spectrometry Facility used in this study.

Supplementary material

The 1 D and 2 D NMR and HREIMS analyses of compound 1 are available as supporting information.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by a grant to the Korea Polar Research Institute, KOPRI, under a project (PE19210).