A new abietane diterpene and anti-complementary constituents from Juniperus tibetica

Abstract

Anti-complementary activity-guided fractionation led to the isolation of a new abietane diterpene (1) and twenty-five known compounds (2–26) from the twigs and leaves of Juniperus tibetica. All the compounds were isolated from J. tibetica for the first time. The structure of 1 was assigned by spectroscopic data and X-ray crystallography analysis. Five lignans (2, 3, 7, 9 and 10), two flavones (19 and 22), and one coumarin (23) exhibited anti-complementary activity with CH₅₀ values ranging from 0.3 to 3.69 mM.

Graphical Abstract

Keywords:

• Juniperus tibetica
• abietane diterpene
• anti-complementary activity

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China [grant number 81673690]; the Ministry of Science and Technology of China [grant number 2019YFC1711006]; the major project of Science and Technology of Tibet autonomous region, China [grant numer XZ201801-GH-13]; and the Development Project of Shanghai Peak Disciplines-Integrative Medicine [grant number 20180101].